Loading word page…
Updated June 2026
a pricking or puncture in medical terminology
“The nyxis of the membrane released the fluid.”
"Nyxis" uses 5 different letters, which makes it efficient for eliminating options. Its 1 vowel balance the consonants. Watch the less-common letter X.
"Nyxis" is worth 15 points before board bonuses. It carries the high-value tile X — land it on a premium square for a big swing.
Change a single letter of “nyxis” to make these 5-letter words — useful for Wordle and crossword clues.
Look up nyxis in an authoritative dictionary for full definitions, pronunciation, and etymology.

Download Word Challenge for unlimited word puzzles, a fresh Daily Challenge, and head-to-head multiplayer. Guess the hidden word in six tries or fewer!