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Updated June 2026
a chronic autoimmune disease; also Latin for wolf
“The lupus diagnosis required long-term treatment.”
lu·pus
"Lupus" repeats a letter (4 unique of 5), so it rules out fewer options as an opening guess. Its 2 vowels balance the consonants.
"Lupus" is worth 7 points before board bonuses. Aim its letters at double/triple-letter and word squares to lift the score.
Change a single letter of “lupus” to make these 5-letter words — useful for Wordle and crossword clues.
Look up lupus in an authoritative dictionary for full definitions, pronunciation, and etymology.
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